Monday 31 August 2015

Novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine bearing substituted phenylquinolin-2-one moiety

General structure of final synthesized derivatives.
Figure 1.
General structure of final synthesized derivatives.



Synthetic Scheme for 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine bearing substituted ...
Scheme 1. 
Synthetic Scheme for 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine bearing substituted phenylquinolin-2-one (4a4t). Where R = H, 2-Br, 3-Br, 4-Br, 2-Cl, 3-Cl, 4-Cl, 2-F, 3-F, 4-F, 2-NO2, 3-NO2, 4-NO2, 2-CH3, 3-CH3, 4-CH3, 2-OCH3, 3-OCH3, 4-OCH3, 3,4,5-t-OCH3. Reagents and conditions: (a) C2H5OH, Nitrobenzene, Con. H2SO4, reflux, 80 °C, 4 h; (b) chloroacetic acid, NaHCO3, water, CuO, reflux, 80 °C, 5 h; (c) thiocarbohydrazide, Δ, 2 h; (d) phenacyl bromide, anhydrous ethanol, NH4OH, 50 °C, 6 h.
 In the present work twenty derivatives of phenylquinoline-1,2,4-triazolothiadiazines were synthesized. The structures of the synthesized compounds were established by spectral data. According to IR spectroscopic data compounds (4a4t) showed peaks at 1306–1330 cm−1, 650–682 cm−1 due to -Ndouble bond; length as m-dashC and Csingle bondSsingle bondC stretching vibrations respectively and no absorption peaks at 3140–3280 cm−1, 3050–3090 cm−1 due to -NH2 and -SH groups respectively indicated smooth cyclization of triazoles leading to the formation of thiadiazine ring. Further, 1H NMR spectra of the synthesized compounds were confirmed by the appearance of Ssingle bondCH2 proton of 1,3,4-thiadiazine ring at 4.40–4.54 ppm and single bondCH2 proton at 5.97–6.20 ppm as broad singlet. All other aromatic protons were observed at expected region. Mass spectra (ESI-MS) of all the synthesized compounds showed molecular ion [M + H]+ peak in agreement with their molecular formula. Physical and elemental analyses are listed in Table 1.


2.6.20. 6,7,8-Trimethoxy-4-phenyl-1-({6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl}methyl)-1,2-dihydroquinolin-2-one (4t)

White needle Crystal; IR (KBr, cm−1): 3023 (Ar Csingle bondH str), 2901 (Aliphatic Csingle bondH str),1706 (Cdouble bond; length as m-dashO str), 1620 (Cdouble bond; length as m-dashN str), 1564 (Cdouble bond; length as m-dashC str), 1330 (Ar Csingle bondN str), 683 (Csingle bondSsingle bondC); 1H NMR (CDCl3, 300 MHz): δ (ppm): 3.84 (s, 9H, 3xOCH3), 4.51 (s, 2H, Ssingle bondCH2single bond), 5.98 (s, 2H, CH2), 6.85 (s, 1H, CHdouble bond; length as m-dash), 7.45(d, 2H, J = 8.5 Hz, Arsingle bondH), 7.48(m,5H, Arsingle bondH), 7.74 (q, 4H, Arsingle bondH). ESI-MS (m/z) calcd. is 539.6, found 540.7 [M + H]+; anal. calcd. for C29H25N5O4S (539.60): C 64.55, H 4.67, N 12.98; found: C 64.54, H 4.63, N 12.95.





 Arabian Journal of Chemistry
 

Available online 11 July 2015
ORIGINAL ARTICLE

Synthesis, characterization and antimicrobial evaluation of some novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine bearing substituted phenylquinolin-2-one moiety

  • a Department of Pharmaceutical Sciences, Faculty of Health Sciences, Allahabad, Uttar Pradesh 211007, India
  • b Department of Pharmaceutical Chemistry, United Institute of Pharmacy, UPSIDC, Naini, Allahabad, Uttar Pradesh 211010, India
Open Access funded by King Saud University
Under a Creative Commons license
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Friday 28 August 2015

Renewable conjugated acids as curatives for high-performance rubber/silica composites

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Sulphur-cured diene-based rubbers generally suffer from insufficient anti-ageing properties, and the curing process involves the use of toxic additives. Renewable conjugated acids are demonstrated to effectively cure epoxidized natural rubber into a high-performance elastomer, without the use of any toxic accelerators or antioxidants.


Graphical abstract: Renewable conjugated acids as curatives for high-performance rubber/silica composites





Renewable conjugated acids as curatives for high-performance rubber/silica composites

*Corresponding authors
aDepartment of Polymer Materials and Engineering, South China University of Technology, Guangzhou, P. R. China
E-mail: psbcguo@scut.edu.cn
Fax: +86 20 22236688
Tel: +86 20 87113374
Green Chem., 2015,17, 3301-3305
 
http://pubs.rsc.org/en/content/articlelanding/2015/gc/c5gc00834d#!divAbstract
DOI: 10.1039/C5GC00834D
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Saturday 15 August 2015

HISPIDIN

Hispidin


Hispidin


ChemSpider 2D Image | Hispidin | C13H10O5 

6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone

cosy, hsqc, ftir seehttp://www.uvu.edu/chemistry/docs/research/hispidin.pdf
HMBC



FTIR




HSQC





http://www.uvu.edu/chemistry/docs/research/hispidin.pdf









Details





Spectral Data
Additional Data
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Type: 13C

Mult.(coupling const.)


CSEARCH-Prediction 0
1 D 134.81
134.2
2 D 120.91
121.2
3 D 116.65
116.8
4 D 115.53
116.4
5 D 113.89
114.6
6 D 100.14
101.6
7 D 89.93
94.5
8 S 127.99
127.6
9 S 169.85
161.8
10 S 160.35
158.3
11 S 146.70
148.4
12 S 145.52
147.1
13 S 162.82
169.2





Spectral Data
Additional Data
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Type: 1H

Mult.(coupling const.)

Intensity
1-H
7.29 (H 19) 1.0
2-H
6.88 (H 21) 1.0
3-H
6.69 (H 20) 1.0
4-H
6.91 (H 22) 1.0
5-H
7.17 (H 23) 1.0
6-H
6.13 (H 24) 1.0
7-H
5.37 (H 25) 1.0
14-H


15-H


16-H









 1H NMR PREDICT







13C NMR PREDICT











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