LITERATURE SEARCH




The ability to access chemical literature is an important skill for the developing chemist. Although the College of Saint Benedict and Saint John’s University chemistry department had implemented a variety of individual exercises into the introductory course sequence to help students develop literature searching skills, second-year students still struggled with the navigation of the bewildering maze of resources, texts, and databases. This article describes an activity for organic laboratory instructors to coach students on how to prioritize and use a multitude of resources to locate a specific literature procedure. This activity is based on the idea that students find a dialogic approach to be more helpful to consolidate learning and applying knowledge.



Department of Chemistry, College of Saint Benedict and Saint John’s University, Saint Joseph, Minnesota 56374, United States
J. Chem. Educ.201592 (1), pp 124–126
DOI: 10.1021/ed500486p
Publication Date (Web): October 15, 2014

*E-mail: kgraham@csbsju.edu.



I Will keep updating info on literature search......keep watching


Case study aspirin, acetyl salicylic acid



1      Google
Google



output is

Aspirin - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Aspirin
Aspirin
Aspirin-skeletal.svg
Aspirin-B-3D-balls.png
Systematic (IUPAC) name
2-(acetoxy)benzoic acid
Clinical data
AHFS/Drugs.commonograph
MedlinePlusa682878
  • AU: C
  • US: C
  • In the 3rd trimester it is US category D.
Legal status
  • AU: Pharmacy Only (S2)
  • UK: GSL
  • US: OTC
  • In Australia it is schedule 2, except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.
RoutesMost commonly oral, also rectal, lysine acetylsalicylate may be given intravenously orintramuscularly
Pharmacokinetic data
Bioavailability80–100%[1]
Protein binding80–90%[2]
MetabolismHepatic, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.[2]
Half-lifeDose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[2]
ExcretionUrine (80–100%), sweat, saliva, feces[1]
Identifiers
CAS number50-78-2 Yes
ATC codeA01AD05 B01AC06,N02BA01
PubChemCID 2244
DrugBankDB00945
ChemSpider2157 Yes
UNIIR16CO5Y76E Yes[FDA]
KEGGD00109 Yes
ChEBICHEBI:15365 Yes
ChEMBLCHEMBL25 Yes
Synonyms2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
PDB ligand IDAIN (PDBeRCSB PDB)
Chemical data
FormulaC9H8O4 
Molecular mass180.157 g/mol
Physical data
Density1.40 g/cm3
Melting point136 °C (277 °F)
Boiling point140 °C (284 °F) (decomposes)
3 mg/mL (20 °C)
 Yes (what is this?)  (verify)

cas no is    
50-78-2 
cas = chemical abstracts service

Most of the info in this page is cut paste




2  Check chemspider

Image result for chemspider

CLICK

http://www.chemspider.com/StructureSearch.aspx

DRAW





OUTPUT IS

ChemSpider 2D Image | Aspirin | C9H8O4



2-(Acetyloxy)benzoic acid
200-064-1 [EINECS]
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoesäure [German] [ACD/IUPAC Name]
2-Acetoxybenzoic acid [ACD/IUPAC Name]
2-Acetyloxybenzoic acid
2-Carboxyphenyl acetate

50-78-2 [RN]   ..................IS THE CAS NUMBER



3 ORGANIC SYNTHESIS

Organic Syntheses

www.orgsyn.org/

Free electronic version of printed Organic Syntheses series - detailed reliable experimental methods for the synthesis of organic compounds.
CLICK
TYPE TEXT ...ASPIRIN ........ NO HITS
SEARCH TEXT CAS NO OPTION 
50-78-2 

NO HITS
MOVE ON



4   SYNARCHIVE







  1. SynArchive - The Organic Synthesis Database

    www.synarchive.com/
    Find organic syntheses, chemical transformations and named reactions through a growing database of chemical synthesis.
  2. Synarchive logo
  3. BROWSE MOLECULE.................NO MOLECULE
  4. BROWSE SYNTHESIS.........NIL






  5. 5 PUBCHEM

  6. pubchem.ncbi.nlm.nih.gov › NCBI › Chemicals & Bioassays › PubChem


    Search By: Name/ Text, Identity/ Similarity, Substructure/ Superstructure, Molecular Formula, 3D Conformer, Saved Search ...
  7. CLICK
  8. OUTPUT IS


  9. MW: 
    180.157420
     g/mol 
    MF: 
    C9H8O4
    IUPAC name: 
    2-acetyloxybenzoic acid

    CID: 
    2244                                     CLICK   TITLE

TO GET OUTPUT AS ON
https://pubchem.ncbi.nlm.nih.gov/compound/2244





6 CHEMSYNTHESIS
http://www.chemsynthesis.com/



NO RESULTS







eMolecules

http://www.emolecules.com/




8 NIST
NIST Data Gateway providing easy access to collections of NIST standard reference data
http://srdata.nist.gov/gateway/gateway?search=substance





9

MOLBASE
http://www.molbase.com/en/index.html


TYPE ACETYLSALICYCLIC ACID OR 

50-78-2 
U WILL GETOUTPUT AS UNDER

http://www.molbase.com/en/search.html?search_type=text&search_keyword=50-78-2

Acetylsalicylic Acid

Synthesis Route (57)
.........ALL SYNTHESIS ON TOP CENTRE


Acetylsalicylic acid NMR spectra analysis, Chemical CAS NO. 50-78-2 NMR spectral analysis, Acetylsalicylic acid H-NMR spectrumNMR



10 WENKU BAIDU

  • 百度文库——让每个人平等地提升自我

    wenku.baidu.com/
    Translate this page
    在线互动式文档分享平台,在这里,您可以和千万网友分享自己手中的文档,全文阅读其他用户的文档,同时,也可以利用分享文档获取的积分下载文档.
  • Baidu In English

    www.baiduinenglish.com/
    Browse and read the wealth of information on the Chinese website Baidu in English. And browse Baidu's search engine in English.





  • this will be updated please


    keep watching everyday.....................





    1 DRUG  SYNTHESIS
    2 CHEMISTRY BY DESIGN
    3 Drug Preparation Database
    4 Drugsee.com
    5 CHEMSPIDER
    6 CHEMSYNTHESIS
    7 API DATABASE
    8 CHEMISTRY DAILY
    9 POPULAR PHARMA DRUGS
    10 CHEMNET
    11 ORGANIC-REACTION

    Home - organic-reaction.com

    12 ORGANIC CHEMISTRY.ORG
    13 RHODIUM
    14 IUPAC
    15 Synthesis of Essential Drugs
    16 RETYROSYN OF DRUGS
    17 Synarchive

    SynArchive - Browse syntheses by molecule

    18 DRUG DATA
    19 VITAMINS
    20 DRUGSDB DATABASE
    21 HET DRUGS
    22  DRUGLEAD
    23  ECDYSONE
    Ecdybase (The Ecdysone Handbook) - a free online ecdysteroids database. Includes ecdysteroid containing products catalogue.
    24
    25
    .......................................................................................................................
    药物合成数据库检索系统
    Drug Preparation Database

    输入检索的药物名称:注:包含通用名、商标名、研发代号、异名等。如Loratadine、Cefpirome.
    输入检索的化学名称:注:包含CA命名、普通命名等。
    输入检索的CAS登记号:注:美国化学文摘登记号。
    数据库说明:
    ◆本数据库提供近7000种已上市或在研药物的药物合成相关的信息,如药品名、结构式、化学名、CAS登记号、分子式、分子量、化学活性、开发阶段、研究机构等。最大的优点是快速检索合成路线,并给出参考文献来源。
    ◆检索条件支持模糊查询,各输入条件间的检索关系为逻辑与(即AND关系)。
    ◆检索条件选择其一即可查询。
    目前本数据库已构建完毕,可提供全部的合成路线文献、结构式及合成路线图。
    http://www.drugfuture.com/Index.html

    weblinks

    ¡Valid CSS! ¡W3C Link Checker! ¡HTML Checked! ¡CSS Checked! ¡Links Checked!¡IW Rank Checker! Section 508 WAI Guidelines ¡PR Tool! ¡WM Tools!¡Alexa! ¡Page Rank R! ¡IW Page Rank Checker! PingDom Submit Express¡HTML Validator! Cynthia Tested WAI Guidelines ¡CentOS! ¡Backlinkcheck.com!¡Build With! FMC Markos Web! ¡WhoIs! Whois TestedWebsite traffic comparisons ¡Site Dossier! ¡Transtats! ¡Site report! Whois!Robtex! Whats that site running? Diseño WebVPN ServicesGet 32 inbound links for free







    ANTHONY MELVIN CRASTO
    DR ANTHONY MELVIN CRASTO Ph.D
    MOBILE-+91 9323115463
    GLENMARK SCIENTIST , NAVIMUMBAI, INDIADR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his  PhD from ICT ,1991,  Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis,  & Searle India ltd, now Rpg lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 25 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.His New Drug Approvals ,  Green Chemistry International,  Eurekamoments in Organic Chemistry  Organic Chemistry by Dr Anthony,  WIX BLOG are some most read chemistry blogsHe has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has  several international drug patents published worldwide .
    He has good proficiency in Technology TransferSpectroscopy Stereochemistry Synthesis, Reactions in Org Chem Polymorphism Pharmaceuticals Medicinal chemistry Organic chemistry literature Patent related site Green chemistry Reagents R & D Molecules Heterocyclic chem Sourcing   etc
    He suffered a paralytic stroke in dec 2006 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on  +91 9323115463, amcrasto@gmail.com














    DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

    Join me on Linkedin

    View Anthony Melvin Crasto Ph.D's profile on LinkedIn

    Join me on Facebook FACEBOOK
    Join me on twitterFollow amcrasto on Twitter     
    Join me on google plus Googleplus

     amcrasto@gmail.com




    Khajuraho Group of Monuments is located in India
    Khajuraho Group of Monuments
    Location of Khajuraho Group of Monuments in India.

    Location in Madhya PradeshLocation in Madhya Pradesh

    1. Khajuraho Group of Monuments - Wikipedia, the free ...

      en.wikipedia.org/wiki/Khajuraho_Group_of_Monuments

      The Khajuraho Group of Monuments are a group of Hindu and Jain temples in Madhya Pradesh, India. About 620 kilometres (385 mi) southeast of New Delhi, ...























    Hotel Chandela - A Taj Leisure Hotel







    No comments:

    Post a Comment