Showing posts with label Fatma SM Abu El-Azm. Show all posts
Showing posts with label Fatma SM Abu El-Azm. Show all posts

Tuesday 22 September 2015

Recent Developments in Chemistry of Phthalazines



From hydrazine and hydrazine derivatives
 
Hydrazine and hydrazine derivatives are the most common reagents used for the synthesis of phthalazinone derivatives via their reactions with phthalic anhydride, phthalides, phthalimides etc.
 
Hydrazines with anhydrides: Several methods were reported for the preparation of phthalazinones derivatives. These methods mainly involve the reaction of phthalic anhydrides with hydrazine hydrate in the presence of acetic acid [42-44].
 
Phthalazinones 5,7-9 were synthesized from commercially available phthalic anhydride in 2-3 steps as depicted in (Scheme 1 and 2) [45-51].
 
Additionally, reaction of phthalic anhydride and aromatic hydrocarbons in the presence of anhydrous aluminum chloride under Friedel-Craft’s conditions afforded 2-aroylbenzoic acids 10 which treated with hydrazine hydrate and hydrazine derivatives to give the phthalazine (2H)-1-one 11,12 [52-57] (Scheme 3).
Recent Developments in Chemistry of Phthalazines
Fatma SM Abu El-Azm*, Mahmoud R Mahmoud, and Mohamed H Hekal
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt
Corresponding Author :Fatma SM Abu El-Azm
Chemistry Department
Faculty of Science
Ain Shams University, Abbassia
Cairo, Egypt, Post code 11566
Tel: 0201220383276
E-mail: ftmsaber@yahoo.com
http://www.omicsonline.org/open-access/recent-developments-in-chemistry-of-phthalazines-2161-0401.1000132.php?aid=40611
 
Citation: El-Azm FSMA, Mahmoud MR, Hekal MH (2015) Recent Developments in Chemistry of Phthalazines. Organic Chem Curr Res 4:132. doi: 10.4172/2161-0401.1000132
Chemistry Department
Faculty of Science
Ain Shams University, Abbassia
Cairo, Egypt








/////Phthalazine derivatives,  Pyrazolophthalazines,  Indazolophthalazines,  [1,2,4] Triazolophthalazines, Fatma SM Abu El-Azm