In search of developing new useful “click reactions”, herein we report the organocatalytic azomethine imine-olefin [3 + 2]-cycloaddition as a new click reaction for the synthesis of drug-like spiroindane-1,3-dione-pyrazolidinones from indane-1,3-diones, aldehydes and N,N-cyclic azomethine imines through amino acid-catalysis. The scope of this new click reaction is demonstrated using many examples with high reactivity, selectivity and yields.
- Catalysis Laboratory, School of Chemistry, University of Hyderabad
- Hyderabad, India 500 046
Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones
DOI: 10.1039/C6OB01009A http://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob01009a#!divAbstract