Showing posts with label synthesis. Show all posts
Showing posts with label synthesis. Show all posts

Thursday 16 November 2017

Synthesis with Catalysts

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Axay Parmar

Axay Parmar

Founder at Synthesis with Catalysts Pvt. Ltd

 

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Synthesis with Catalysts Pt. Ltd. is a company started with an aim to produce chiral and achiral precious metal based catalysts on commercial scale in line with “Clean and Green India” and “Make in India” vision of Government of India. These catalysts have been developed to promote efficient, economical and environmentally benign processes for the target compounds being produced in aroma, fine chemicals and pharmaceutical industries. These catalysts and their intermediates are also extensively used in academic and industrial R&D centres across globe. In India these catalysts are currently imported at a very prohibitive cost, due to which their use is limited for want of funds. In this direction Synthesis with Catalysts Pvt. Ltd. is striving to make these products available to indigenously available at a very competitive price at small and bulk scale. We are also doing in-house research to optimize process parameters ofvarious organic transformations particularly asymmetric hydrogenation and isomerization reactionsfor customers as and when required.
For the list of our products please visit our wesitewww.synthesiswithcatalysts.com
ABOUT US
  • Our vision is to be the most respected catalyst manufacturing company in the country
  • Our goal is to help our customers:
  • to further improve their production methodologies
  • increase productivity,
  • develop new products with the intervention of catalysts to make the process green and clean
  • Highly selective catalysts for intended application
  • Competitive pricing with short delivery lead times
  • Custom product and process development
Activities:A
Manufacture of Homogeneous catalysts using metal ions viz. Rh, Pt, Ir, Pd, Ru, Co, and Mn
Manufacture of ligands and intermediates
Pharmaceutical, bulk drugs, API, aroma chemical, essential oil industries served
Focus on chiral chemistries
Gram to kilogram quantities
ASYMMETR

Some of the representative reactions are:

ASYMMETRIC/ CHEMOSELECTIVE HYDROGENATION CATALYSTS
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Statements
  • Catalysts are chiral metal complexes derived from a precious metal ion and chiral ligands
  • Ru used most frequently, Rh used in some cases to enhance chemo- and enantio- selectivity
  • Chiral ligands can be selected from variety of simple and substituted BINAP alone or in combination with chiral/achiral diamines
  • Suggested catalysts:
    • RuCl2[(S)-BINAP](dmf)n
    • RuCl2[(S)- tolBINAP][(S,S)-dpen]
    • (S)-XylBINAP/(S)-DAIPEN-Ru
    • (S)-XylBINAP/(S,S)-DPEN-Ru
    • RuCl2[(S)-tolBINAP](pica)
    • RuCl[(S,S)-TsDPEN](η6-p-cymene)
    • Ru(OTf)(TsDPEN)(p-cymene)
    • BINAP-Ru(II) dicarboxylate complexes

ENANTIOSELECTIVE EPOXIDATION / HKR / DKR

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Statements:
  • Transition metal complexes are used for chiral and non-chiral epoxidation of internal and prochiral olefins
  • The epoxides are important intermediates for host of industrially important products
  • In cases where epoxides are required in high optical purity, racemic epoxides can be subjected to Hydrolytic kinetic resolution (HKR), Aminolytic kinetic resolution (AKR), Dynamic kinetic resolutions (DKR)
  • Suggested catalysts:
    • Mn, Co, Cr, Al complexes of chiral SALEN ligands
ASYMMETRIC ISOMERIZATION

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Double bond migration reactions
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Statements:
  • Rh-catalyzed asymmetric isomerization of allylic amines into the corresponding enamines is one of the most revered industrial organic transformation in asymmetric catalysis
  • It has accommodated a wide range of substrates and is a key step in the industrial production of menthol
  • Other industrially important isomerization is migration of terminal double bond to produce selectively trans-internal olefins
  • Commercially important products like isoeugenol and trans-anetheole are produced by these transformations
  • Suggested catalysts:
    • Ru(acac)3
    • RuHCl(CO)(PPh3)3
    • Rh/Pd complexes
Tree of popular asymmetric organic transformations

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At Chiral India event in Mumbai where our technical director Dr. Abdi Is a speaker. With Basu Agarwal
Basu Agarwal

Basu Agarwal

CEO at Synthesis with Catalysts Pvt Ltd
Phone 9999972051 (Mobile)
Email
IM basu.ag@gmail.com (Google Talk)
Chiral India 2017, Nov7-8 Ramada plaza palm grove, Juhu, Mumbai, India
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Sunday 6 March 2016

Synthesis of vinyl ethers of alcohols using calcium carbide under superbasic catalytic conditions (KOH/DMSO)



Green Chem., 2016, Advance Article
DOI: 10.1039/C5GC02977E, Communication
Ryosuke Matake, Yusuke Adachi, Hiroshi Matsubara
A convenient preparation of vinyl ethers from alcohols with calcium carbide was developed. This protocol is an alternative to the Favorskii-Reppe reaction without any high pressure device.


 Vinyl ethers are important and useful synthetic building blocks. Using a test tube with a screw cap, a convenient preparation of vinyl ethers from alcohols with calcium carbide under superbasic catalytic conditions (KOH/DMSO) was developed. The vinylation of primary and secondary alcohols was successfully achieved, affording the desired products in good yields. The gram-scale preparation of a vinyl ether was also demonstrated. In this reaction, calcium carbide acts as an acetylene source, constituting a safer alternative to acetylene gas.





 F. de Nanteuil, E. Serrano, D. Perrotta and J. Waser, J. Am. Chem. Soc., 2014, 136, 6239.


1H NMR

1H NMR PREDICT using nmrdb , signals may vary , use your discretion to understand sequence



13C NMR



13 C NMR PREDICT




 

 

 

 

 

 

 

 

 

 

 

 

 

 

Synthesis of vinyl ethers of alcohols using calcium carbide under superbasic catalytic conditions (KOH/DMSO)



*
Corresponding authors
a
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Japan
E-mail: matsu@c.s.osakafu-u.ac.jp
Green Chem., 2016, Advance Article

DOI: 10.1039/C5GC02977E ////////////////////

Saturday 19 September 2015

GREEN ACETANILIDE SYNTHESIS AND SPECTRAL ANALYSIS










 



 

















 



 



H-1 NMR Spectrum of Acetanilide

The following chemical shifts were reported [1,2] for the protons of acetanilide:
CH3 [1] 2.1
para-H [1] 7.0
meta-H [1] 7.2
ortho-H [1] 7.4
NH [2] ca. 8.75
[1] M. Hesse, H. Meier, B. Zeeh: Spektroskopische Methoden in der organischen Chemie, Georg Thieme Verlag, Stuttgart, 2nd ed., 1984, p. 263.
[2] from a H-1 NMR spectrum shown by Stephen Jones


C-13 NMR Spectrum of Acetanilide

The following chemical shifts were reported [1] for the carbons of acetanilide:
CH3 [1] 24.1
para-C [1] 124.1
meta-C [1] 128.7
ortho-C [1] 120.4
ipso-C [1] 138.2
CO [1] 169.5
[1] M. Hesse, H. Meier, B. Zeeh: Spektroskopische Methoden in der organischen Chemie, Georg Thieme Verlag, Stuttgart, 2nd ed., 1984, p. 263.
[2] there is a C-13 NMR spectrum shown by Stephen Jones



Acetanilide
Acetanilide
Names
IUPAC names
N-phenylacetamide
N-phenylethanamide
Identifiers
103-84-4 Yes
ChEBI CHEBI:28884 Yes
ChEMBL ChEMBL269644 Yes
ChemSpider 880 Yes
EC number 203-150-7
Jmol-3D images Image
KEGG C07565 Yes
UNII SP86R356CC Yes
Properties[1][2]
C8H9NO
Molar mass 135.17 g·mol−1
Odor Odorless
Density 1.219 g/cm3
Melting point 114.3 °C (237.7 °F; 387.4 K)
Boiling point 304 °C (579 °F; 577 K)
<0.56 g/100 mL (25 °C)
Solubility Soluble in ethanol, diethyl ether, acetone, benzene
log P 1.16 (23 °C)
Vapor pressure 2 Pa (20 °C)
Hazards[3][4]
Safety data sheet External MSDS
GHS pictograms Acute Tox. (oral) 4
GHS signal word WARNING
H302
P264, P270, P301+312, P330, P501
Flash point 174 °C (345 °F; 447 K)
545 °C (1,013 °F; 818 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 Yes verify (what isYes/?)
Infobox references




Drying acetanilide



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